‘This comprehensive book is welcome at this point of rapid growth in new technologies and discoveries such that keeping up with applications of genome engineering is challenging. Here we have both a general introduction to the field and to deep mechanisms and glimpses of future applications and ethical considerations – with gems for newcomers and experts alike.’ George M. Church, Harvard University, Massachusetts and Massachusetts Institute of Technology

‘Krishnarao Appasani has assembled a comprehensive series of up-to-date chapters on endonuclease-based genomic engineering by experts and practitioners. The book presents a wide range of topics from basic science, applications to genetic screens and diseases, and legal and ethical issues. The many potential applications across a wide range of organisms are well illustrated.

The book will become a must have for any researchers in academia and industry trying to keep up with this fast-moving field.’ Norbert Perrimon, Harvard Medical School, Boston